PTMs and Splice Variants

PTMs and Splice Variants
Post-translational modifications (PTMs) are essential for cellular control mechanisms, which affects protein activity and functions. PTMs play a key role in various disease conditions including cancer. Alternative splicing is a crucial mechanism for generating protein diversity. Different splice variants of a given protein exhibit different biological functions. Alternative splicing shows a major role in tumor development and progression. Analysis of PTMs and splice variants is still a challenging task since these are low abundant and sub-stoichiometric. Mass spectrometry is widely used for the analysis of PTMs and splice variants. This session would discuss the successful strategies to identify and characterize PTMs and splice variants using advanced mass spectrometry based proteomic approaches. /div>


Dr. Chunaram Choudhary
Novo Nordisk Foundation Center for Protein Research (CPR), University of Copenhagen, Denmark

Dr. Ravi Sirdeshmukh
Mazumdar Shaw Center for Translational Research, Bangalore, India

Dr. Mahesh J. Kulkarni
CSIR - National Chemical Laboratory, Pune, India.

Dr. Tushar K. Maiti
Regional Centre for Biotechnology, Faridabad, India

Dr. Alka Rao
CSIR - Institute of Microbial Technology, Chandigarh, India

Dr. Swasti Raychaudhuri
CSIR - Centre for Cellular & Molecular Biology, Hyderabad, Telangana, India